This page lists our publications sorted by date. You can also find our Presentations and Posters on their own pages.


  • A comprehensive two-dimensional liquid chromatography method for the simultaneous separation of lipid species and their oxidation products, E. Lazaridi, H. Janssen, J. Vincken, B.W.J. Pirok, M. Hennebelle, J. Chromatogr. A, 2021, 1644, 462106, DOI: 10.1016/j.chroma.2021.462106 [OPEN ACCESS]
  • Peak-tracking algorithm for use in comprehensive two-dimensional liquid chromatography – application to monoclonal-antibody peptides, S.R.A. Molenaar, T.A. Dahlseid, G. Leme, D.R. Stoll, P.J. Schoenmakers, B.W.J. Pirok, J. Chromatogr. A, 2021, 1639, 461922, DOI: 10.1016/j.chroma.2021.461922 [OPEN ACCESS]
  • Measuring and using scanning-gradient data for use in method optimization for liquid chromatography M.J. den Uijl, P.J. Schoenmakers, G.K. Schulte, D.R. Stoll, M.R. van Bommel, B.W.J. Pirok, J. Chromatogr. A, 2021, 1636, 461780, DOI: 10.1016/j.chroma.2020.461780 [OPEN ACCESS]
  • Reducing the influence of geometry-induced gradient deformation in liquid chromatographic retention modelling, T.S. Bos, L.E. Niezen, M.J. den Uijl, S.R.A. Molenaar, S. Lege, P.J. Schoenmakers, G.W. Somsen, B.W.J. Pirok, J. Chromatogr. A, 2021, 1635, 461714, DOI: 10.1016/j.chroma.2020.461714 [OPEN ACCESS]


  • Accurate modelling of the retention behaviour of peptides in gradient-elution hydrophilic interaction liquid chromatography
    L.S. Roca, S.E. Schoemaker, B.W.J. Pirok, A.F.G. Gargano, P.J. Schoenmakers, J. Chromatogr. A, 1614, 2020, 460650, DOI: 10.1016/j.chroma.2019.460650 [OPEN ACCESS]
  • Recent applications of chemometrics in one- and two-dimensional chromatography
    T.S. Bos, W.C. Knol, S.R.A. Molenaar, L.E. Niezen, P.J. Schoenmakers, G.W. Somsen, B.W.J. Pirok, J. Sep. Sci. 43(9-10), 2020, 1678-1727, DOI: 10.1002/jssc.202000011 [OPEN ACCESS]
  • Challenges in Obtaining Relevant Information from One- and Two-Dimensional LC Experiments
    B.W.J. Pirok & J.A. Westerhuis, LC-GC North America, 6(38), 2020, 8-14, [LINK] [OPEN ACCESS]
  • Parallel gradients in comprehensive multidimensional liquid chromatography enhance utilization of the separation space and the degree of orthogonality when the separation mechanisms are correlated
    A.A. Aly, M. Muller, A. de Villiers, B.W.J. Pirok, T. Górecki, J. Chromatogr. A, 1628, 2020, 461452, DOI: 10.1016/j.chroma.2020.461452 [OPEN ACCESS]
  • Book Chapter: Liquid Chromatography: Applications for the Oil and Gas Industry
    D. van Herwerden, B.W.J. Pirok, P.J. Schoenmakers, Analytical Techniques in the Oil and Gas Industry for Environmental Monitoring, 2020, DOI: 10.1002/9781119523314.ch5
  • Retention applications of retention modelling in liquid chromatography
    M.J. den Uijl, P.J. Schoenmakers, B.W.J. Pirok, M.R. van Bommel, J. Sep. Sci. 2020 in print, DOI: 10.1002/jssc.202000905 [OPEN ACCESS]
  • Detection challenges in quantitative polymer analysis by liquid chromatography
    W.C. Knol, B.W.J. Pirok, R.A.H. Peters, J. Sep. Sci, 2020, in print, DOI: 10.1002/jssc.202000768 [OPEN ACCESS]


  • Mapping Degradation Pathways of Natural and Synthetic Dyes with LC-MS: Influence of Solvent on Degradation Mechanisms
    B.W.J. Pirok, G. Moro, N. Meekel, S.V.J. Berbers, P.J. Schoenmakers and M.R. van Bommel, J. Cult. Heritage, 38, 2019, 29-36, DOI: 10.1016/j.culher.2019.01.003 
  • Recent Developments in Two-Dimensional Liquid Chromatography: Fundamental Improvements for Practical Applications
    B.W.J. Pirok, D.R. Stoll and P.J. Schoenmakers, Anal. Chem., 2019, 91(1), 240-263, DOI: 10.1021/acs.analchem.8b04841 [OPEN ACCESS]
  • Making Incompatible Approaches Compatible (MANIAC)
    B.W.J. Pirok, 2019, ISBN: 9789463752817, Faculty of Science (FNWI), University of Amsterdam. [LINK] [OPEN ACCESS]
  • On-line Microfluidic Immobilized-Enzyme Reactors: A New Tool for Characterizing Synthetic Polymers
    B. Wouters, B.W.J. Pirok, D. Soulis, R.C. Garmendia Perticarini, S. Fokker, R.S. van den Hurk, M. Skolimowski, R.A.H. Peters and Peter J. Schoenmakers, Anal. Chim. Acta., 2019, 1053, 62-69, DOI: 10.1016/j.aca.2018.12.002 [OPEN ACCESS]
  • Heterogeneity analysis of polymeric carboxylic acid functionality by selective derivatization followed by size exclusion chromatography
    T. Brooijmans, R.A. Okhuijsen, G.M.M. Oerlemans, B.W.J. Pirok, P.J. Schoenmakers, R.A.H. Peters, Anal. Chim. Acta, 1072, 2019, 87-94, DOI: 10.1016/j.aca.2019.04.051
  • Computer-aided gradient optimization of hydrophilic interaction liquid chromatographic separations of intact proteins and protein glycoforms
    G. van Schaick, B.W.J. Pirok, R. Haselberg, G.W Somsen, A.F.G Gargano, J. Chromatogr. A, 1598, 2019, 67-76, DOI: 10.1016/j.chroma.2019.03.038 [OPEN ACCESS]
  • Perspectives on the Future of Multi-dimensional Platforms
    G. Groeneveld, B.W.J. Pirok and P.J. Schoenmakers, Faraday Discuss., 218, 2019, 72-100, DOI: 10.1039/C8FD00233A
  • Clinical Metabolomics: Expanding the Metabolome Coverage Using Advanced Analytical Techniques
    R. Haselberg, I. Kohler, B.W.J. Pirok, A.F.G. Gargano, LC-GC Europe, 37(12), 2019, 878-887, [LINK] [OPEN ACCESS]
  • Characterization of Dye Extracts from Historical Cultural-Heritage Objects using State-of-the-Art Comprehensive Two-Dimensional Liquid Chromatography and Mass Spectrometry with Active Modulation and Optimized Shifting Gradients
    B.W.J. Pirok, M.J. den Uijl, G. Moro, S.V.J. Berbers, C.J.M. Croes, M.R. van Bommel and P.J. Schoenmakers, Anal. Chem., 91(4) 2019, 3062-3069, DOI: 10.1021/acs.analchem.8b05469 [OPEN ACCESS]
  • Analysis of Charged Acrylic Particles by On-line Comprehensive Two-Dimensional Liquid Chromatography and Automated Data-Processing
    B.W.J. Pirok, N. Abdulhussain, T. Brooijmans, T. Nabuurs, J. de Bont, M.A.J. Schellekens, R.A.H. Peters and P.J. Schoenmakers, Anal. Chim. Acta., 2019, 1054, 184-192, DOI: 10.1016/j.aca.2018.12.059 [OPEN ACCESS]


  • Peak-Tracking Algorithm for Use in Automated Interpretive Method-Development Tools in Liquid Chromatography
    B.W.J. Pirok, S.R.A. Molenaar, L.S. Roca and P.J. Schoenmakers, Anal. Chem., 2018, 90(23), 14011-14019, DOI: 10.1021/acs.analchem.8b03929 [OPEN ACCESS]
  • Comprehensive Two-Dimensional Liquid Chromatography of Heavy Oil
    F.T. van Beek, R. Edam, B.W.J. Pirok, W.J.L. Genuit and P.J. Schoenmakers, J. Chromatogr. A, 2018, 1564, 110-119. DOI: 10.1016/j.chroma.2018.06.001 [OPEN ACCESS]
  • Practical Approaches for Overcoming the Challenges of Comprehensive Two-Dimensional Liquid Chromatography
    B.W.J. Pirok and Peter J. Schoenmakers, LC-GC Europe, 2018, 31, 242–249 [LINK] [OPEN ACCESS]
  • Optimizing separations in online comprehensive two-dimensional liquid chromatography
    B.W.J. Pirok, A.F.G. Gargano and P.J. Schoenmakers, J. Sep. Sci., 2018, 41(1), 68–98, DOI: 10.1002/jssc.201700863 [OPEN ACCESS]
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Recent Posts

Peak Tracking for Use in 2D-LC

Working with comprehensive 2D-LC (LC×LC) data can be highly challenging. This is particularly true for complex samples. Together with the group of Dwight Stoll, Stef Molenaar developed a pack-tracking algorithm to solve this.