This tool is currently under active development, and the website is undergoing testing.
This tool is currently under active development, and the website is undergoing testing.
CAST Scientst Masashi Serizawas was published in Macromolecules. Masashi presents a ‘polymer sequencing’ approach for analyzing the composition of PLGA copolymers in great detail. The method consists of controlled chemical degradation followed by reversed-phase liquid chromatography and high-resolution mass spectrometry (RPLC-HRMS) to arrive at an accurate characterisation of block-length distribution. The work provides a robust framework for the rational design of sequence-controlled PLGA for drug delivery and other advanced applications.
In this study, CAST scientists Annika van der Zon et al., in collaboration with Bram Weijers and Danielle Vlugts (Amsterdam UMC), introduce a rapid, microscale aqueous size-exclusion chromatography–mass spectrometry (SEC-MS) method to measure chelator to antibody ratio in immunoconjugates.
The study addresses size-resolved surface charge density (SCD) analysis of polymer nanoparticles (PNPs), revealing the significant variability of SCD that traditional methods overlook. By employing advanced capillary zone electrophoresis techniques, researchers can gain detailed insights into nanoparticle performance, benefiting applications in coatings, biomedical, and industrial contexts through collaborative innovations.