2D-LC Bounding Gradient

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Novel sequencing approach enables detailed characterization of PLGA co-polymers

CAST Scientst Masashi Serizawas was published in Macromolecules. Masashi presents a ‘polymer sequencing’ approach for analyzing the composition of PLGA copolymers in great detail. The method consists of controlled chemical degradation followed by reversed-phase liquid chromatography and high-resolution mass spectrometry (RPLC-HRMS) to arrive at an accurate characterisation of block-length distribution. The work provides a robust framework for the rational design of sequence-controlled PLGA for drug delivery and other advanced applications.

Microscale native SEC-HRMS to characterize immunoconjugates

In this study, CAST scientists Annika van der Zon et al., in collaboration with Bram Weijers and Danielle Vlugts (Amsterdam UMC), introduce a rapid, microscale aqueous size-exclusion chromatography–mass spectrometry (SEC-MS) method to measure chelator to antibody ratio in immunoconjugates.

Bob Pirok receives LCGC Emerging Leader award

Bob Pirok has been named winner of the 2026 LCGC International Emerging Leader in Chromatography Award, recognizing his contributions to automated method development, LC×LC, chemometrics, and artificial intelligence in separation science.