Novel sequencing approach enables detailed characterization of PLGA co-polymers
CAST Scientst Masashi Serizawas was published in Macromolecules. Masashi presents a ‘polymer sequencing’ approach for analyzing the composition of PLGA copolymers in great detail. The method consists of controlled chemical degradation followed by reversed-phase liquid chromatography and high-resolution mass spectrometry (RPLC-HRMS) to arrive at an accurate characterisation of block-length distribution. The work provides a robust framework for the rational design of sequence-controlled PLGA for drug delivery and other advanced applications.
