On Thursday January 30th, 2020, CAST member Bob Pirok gave a tutorial titled Advances in 2D-LC. The tutorial described the basic principles of 2D-LC, including data formatting, shifting gradients, method development and modulation. Specific attention was given to recent developments in the field. Please find the slides and cited literature here.
Novel sequencing approach enables detailed characterization of PLGA co-polymers
CAST Scientst Masashi Serizawas was published in Macromolecules. Masashi presents a ‘polymer sequencing’ approach for analyzing the composition of PLGA copolymers in great detail. The method consists of controlled chemical degradation followed by reversed-phase liquid chromatography and high-resolution mass spectrometry (RPLC-HRMS) to arrive at an accurate characterisation of block-length distribution. The work provides a robust framework for the rational design of sequence-controlled PLGA for drug delivery and other advanced applications.
