Where the 2D-LC method database provides easy access to applications that have been developed since 1978, it does not contain publications that describe no dedicated application. Such studies and reviews are instead listed here in the 2D-LC technical literature database.
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Please contact us for any missing references or other feedback.
Topic | Category | Focus | Reference |
---|---|---|---|
Technical study on use of packed loops in 2D-LC | Modulation | Injection | Knol et al. (2023) |
Technical study on segmented 2D-LC | Fundamentals | Optimization | Hrůzová et al. (2023) |
Optimizing transfer and dilution for 2D-LC with ASM | Modulation | Optimization | Pardon et al. (2023) |
Recent Applications of 2D-LC in Food Analysis | Food | Periodic Overview | Liang et al. (2022) |
Feature-mining algorithm for polymer separations by 2D-LC | Chemometrics | Data Analysis | Molenaar et al. (2022) |
Approaches to Circumvent Solvent Incompatibility in online 2D-LC | Modulation | Injection | Chapel et al. (2022) |
Use of modelling for 2D-LC optimization for pharmaceutical separations | Chemometrics | Optimization | Makey et al. (2021) |
Use of constant pressure in second dimension of 2D-LC | Second Dimension | Optimization | Shoykhet et al. (2021) |
Study on use of scouting gradients for optimization | Gradients | Optimization | den Uijl et al. (2021) |
RPLC vs HILIC as first dimension for Phenolic Content analysis in 2D-LC | First Dimension | Column Selection | Cacciola et al. (2021) |
Review on recent heart-cutting 2D-LC applications | Applications | Periodic Overview | Dsouza et al. (2021) |
Review on multi-dimensional analysis of polyolefins | Applications | Periodic Overview | Pasch et al. (2021) |
Review on analysis comprehensive 2D-LC using ROI and MCR methods | Chemometrics | Data Analysis | Pérez-Cova et al. (2021) |
Review on 3D separations | Applications | General | Abdulhussain et al. (2021) |
Review on 2D-LC in metabolomics and lipidomics | Applications | Periodic Overview | Pérez-Cova et al. (2021) |
Peak-tracking algorithm for 2D-LC | Chemometrics | Data Analysis | Molenaar et al. (2021) |
Opportunities and challenges of LC coupled to SFC | Modulation | SFC | Burlet-Parendel et al. (2021) |
Method for online reduction and digestion of mAbs | Applications | Biopharma | Pot et al. (2021) |
Dispersion in connection capillaries for flow-splitting interfaces | Fundamentals | General | Gunnarson et al. (2021) |
Bayesian optimization for 2D-LC | Chemometrics | Optimization | Boelrijk et al. (2021) |
2D-LC for antibody-based therapeutics review | Applications | Periodic Overview | Camperi et al. (2021) |
Review on use of chemometrics in 2D-LC | Chemometrics | Periodic Overview | Bos et al. (2020) |
Review on LC of alkaloids in herbal medicines (incl 2D-LC) | Applications | Periodic Overview | Zhao et al. (2020) |
Review on amino acid analysis by LC-MS (and 2D-LC) | Applications | Periodic Overview | Violi et al. (2020) |
Review on 2D-LC of therapeutic oligonucleotides | Applications | Periodic Overview | Goyon et al. (2020) |
Review on 2D-LC for food and food products | Applications | Periodic Overview | Cacciola et al. (2020) |
Review of 2D-LC for traditional Chinese medicine | Applications | Periodic Overview | Zhou et al. (2020) |
Multicolumn 2D-LC Screening Workflow for Method Development | Method Development | Column Selection | Wang et al. (2020) |
Modeling of solute injection from modulation valve in 2D-LC | Modulation | Injection | Weatherbee et al. (2020) |
Evaluation of multilinear behavior of comprehensive 2D-LC data | Chemometrics | Data Analysis | Pérez-Cova et al. (2020) |
Data Structure Driven Perspective on Chemometrics in Comprehensive 2D-LC | Chemometrics | Data Analysis | Pérez-Cova (2020) |
Application of 2D-LC for TCM Analysis | Applications | Periodic Overview | Zhou et al. (2020) |
Analyte breakthrough from sampling loops in 2D-LC | Modulation | Injection | Moussa et al. (2020) |
Two New Metrics for Orthogonality | Fundamentals | Quality Descriptors | Mommers et al. (2019) |
Study on re-equilibration in HILIC as second dimension | Second Dimension | Gradients | Seidl et al. (2019) |
Study on partial equilibration in HILIC | Applications | Biopharma | Heaton et al. (2019) |
Review on online 2D-LC modulation technology | Modulation | Periodic Overview | Chen et al. (2019) |
Recent Developments in Two-Dimensional Liquid Chromatography | Applications | Periodic Overview | Pirok et al. (2019) |
Recent advances in 2DLC for Monoclonal Antibodies and Therapeutic Proteins | Applications | Periodic Overview | Stoll et al. (2019) |
Re-equilibration in HILIC as Second-Dimension for 2D-LC | Second Dimension | Gradients | Seidl et al. (2019) |
Outlook in Future Developments of Multi-dimensional Separations | General | Outlook | Groeneveld et al. (2019) |
New At-Column Dilution Modulator | Modulation | Active Interfaces | Chen et al. (2019) |
Multidimensional LC-MS for Metabolomics and Lipidomics | Applications | Periodic Overview | Lv et al. (2019) |
Improved peak-clustering algorithm | Chemometrics | Peak Detection | Xu et al. (2019) |
Immobilized-enzyme reactor for LC and future 2DLC | Modulation | Reaction Modulation | Wouters et al. (2019) |
Hydrophobic subtraction model for 2DLC column selection | Method Development | Column Selection | Lindsey et al. (2019) |
Comparison of Core-Shell and Fully-Porous particles for Second-dimension | Second Dimension | Column Technology | Ahmad et al. (2019) |
Calometric Approach for pH Measurement in LC | Fundamentals | Injection | Leme et al. (2019) |
Band Broadening Effects in Spatial 2D-LC in Microfluidic Devices | Fundamentals | Spatial | Adamopoulou et al. (2019) |
Applied 2D-LC in Foodomics | Food | Periodic Overview | Montero et al. (2019) |
Antibody–Drug Conjugate by 2D-LC using online digestion | Applications | Biopharma | Goyon et al. (2019) |
Advance in 2D-LC Modulation Technology | Modulation | Periodic Overview | Chen et al. (2019) |
Size-Exclusion Chromatography with Superficially Porous Particles | Second Dimension | Column Technology | Schure et al. (2017) |
Size-exclusion chromatography using Core-shell Particles | Second Dimension | Column Technology | Pirok et al. (2017) |
Optimizing Separations in 2D-LC | Fundamentals | General | Pirok et al. (2017) |
State of the Art Tutorial for Using 2D-LC | Fundamentals | General | Stoll et al. (2016) |
Program for Interpretive Optimization Two-dimensional Resolution | Method Development | Optimization | Pirok et al. (2016) |
Practical Considerations for Comprehensive 2D-LC with RPLC in Both Dimensions | Method Development | Column Selection | Li et al. (2015) |
Monolithic and Core-shell Columns in Comprehensive 2D-LC | Method Development | Column Technology | Jandera et al. (2015) |
Improved Accuracy of Quantitation in 2D-LC using Multivariate Curve Resolution | Chemometrics | Quantification | Cook et al. (2015) |
Effect of Pressure Pulses on Second-dimension Columns | Modulation | Injection | Talus et al. (2015) |
Comparison of Orthogonality Metrics by Statistical Analysis | Fundamentals | Quality Descriptors | Schure et al. (2015) |
Theoretical and Practical Interest in UHPLC Technology for 2D-LC | Fundamentals | Quality Descriptors | Sarrut et al. (2014) |
Reversed-Phase Column Pairs in Comprehensive 2D-LC | Method Development | Column Selection | Allen et al. (2014) |
Comparison of One and Multi-dimensional Modes LC Modes | Fundamentals | Quality Descriptors | Davis et al. (2014) |
Application of 2D-LC in Bioanalysis of Drugs and Toxicants | Applications | Pharmaceuticals | Xiao et al. (2014) |
2D-LC for Analysis of Chinese Herbal Medicines | Applications | Natural medicines | Cao et al. (2014) |
Comprehensive 2D Chromatography in Food Analysis | Applications | Foodomics | Tranchida et al. (2013) |
Comparison of Chemometric Methods for Wine Analysis by Comprehensive 2D-LC | Chemometrics | Data Analysis | Bailey et al. (2013) |
Comparison between 1D-LC and Comprehensive 2D-LC | General | Technical Comparison | Potts et al. (2013) |
2D-LC for Direct Chiral Separations | Applications | Chiral Separations | León-González et al. (2013) |
Semi-automated Alignment and Quantification of Peaks in Comprehensive 2D-LC | Chemometrics | Preprocessing | Allen et al. (2012) |
Principles of Online Comprehensive MDLC | Fundamentals | General | Carr et al. (2012) |
Pareto-Optimality Study for Comparison of Comprehensive 2D-LC Modes | Fundamentals | Quality Descriptors | Vanhoutte et al. (2012) |
Optimum Gradient Conditions for Fast Second-dimension Separations | Second Dimension | Optimization | Hájek et al. (2012) |
Method Development in Comprehensive 2D-LC | Method Development | Optimization | Bedani et al. (2012) |
Influence of Temperature on Peak Shape for 2D-LC | Fundamentals | Kinetics | Haun et al. (2012) |
Impact of Probe Solutes on Orthogonality Assessment | Fundamentals | Quality Descriptors | Bakain et al. (2012) |
Gradients in Comprehensive 2D-LC | Method Development | Gradients | Pavel Jandera (2012) |
Feature generation from non-targeted analysis by comprehensive 2D-LC | Chemometrics | Data Analysis | Reichenbach et al. (2012) |
Development for Comprehensive 2D-LC Method for Charged Compounds | Method Development | Optimization | D'Attoma et al. (2012) |
Determination of Peak Distribution in Comprehensive 2D-LC | Fundamentals | Quality Descriptors | Dück et al. (2012) |
Comprehensive 2D-LC Practical Impacts of Theoretical Considerations | Method Development | Optimization | Pavel Jandera (2012) |
Thermal Modulation for Multi-dimensional LC Separations | Modulation | Active Interfaces | Verstraeten et al. (2011) |
Review of Chemometrics Applied to Comprehensive Separations from 2008-2010 | Chemometrics | Periodic Overview | Pierce et al. (2011) |
Resolution and Quantification in Comprehensive 2D-LC of Human Urine | Chemometrics | Quality Descriptors | Bailey et al. (2011) |
Reconstruction of First dimension from Comprehensive 2D-LC Data | Chemometrics | First Dimension | Allen et al. (2011) |
Optimization of Peak Capacity in Comprehensive 2D-LC | Method Development | Quality Descriptors | Gu et al. (2011) |
Factors Effecting Quantification in Diode-array Detector 2D-LC Data | Chemometrics | Quantification | Bailey et al. (2011) |
Effect of Sampling Time Effects on Resolving Power in 2D-LC | Method Development | Optimization | Huang et al. (2011) |
Effect of Gradient Profile and Sample Volume and Solvent to Very Fast Gradients | Method Development | Optimization | Jandera et al. (2011) |
Effect of First-dimension Phase Selectivity in On-line Comprehensive 2D-LC | First Dimension | Column Selection | Gu et al. (2011) |
Effect of First-dimension Eluent Composition in 2D-LC | First Dimension | Optimization | Li et al. (2011) |
Targeted Data Extraction for Comprehensive 2D-LC | Chemometrics | Data Analysis | Reichenbach et al. (2010) |
Simulation of 2D-LC of Diblock Copolymers | Applications | Polymers | Gorbunov etal. (2010) |
Selection of Parameters for Optimization of Comprehensive Off-line 2D-LC | Method Development | Optimization | Eeltink et al. (2010) |
Second-dimension Gradient Types in Comprehensive 2D-LC | Second Dimension | Gradients | Jandera et al. (2010) |
Precision and Accuracy of Peak Quantification in Comprehensive 2D-LC | Chemometrics | Quantification | Thekkudan et al. (2010) |
Optimization of 2D-LC Systems using Pareto-Optimality Approach | Chemometrics | Optimization | Vivó-Truyols et al. (2010) |
Effect of Sampling Time on Peak Capacity and Analysis Speed in Comprehensive 2D-LC | Method Development | Optimization | Potts et al. (2010) |
Development of Micro-Electrochemical Array Detector for 2D-LC | Detection | Electrochemical | Abia et al. (2010) |
2D-LC of Synthetic polymers | Polymers | Periodic Overview | Dušan Berek (2010) |
Peak-Pattern Matching with Comprehensive 2D-LC | Chemometrics | Data Analysis | Reichenbach et al. (2009) |
Overview of Data Analysis Programs for 2D-LC and 2D-GC | Chemometrics | Data Analysis | Kallio et al. (2009) |
Overview of Comprehensive 2D-LC Applications | Applications | Periodic Overview | François et al. (2009) |
Optimization Strategies for Off-line 2D-LC | Method Development | Optimization | Horváth et al. (2009) |
Optimization of 2D-LC Gradient Separations | Method Development | Optimization | Česla et al. (2009) |
On-line Multidimensional LC using Multiple Columns in Parallel | Fundamentals | General | Fairchild et al. (2009) |
Generation and Limitations of Peak Capacity in 2D-LC | Fundamentals | Quality Descriptors | Horváth et al. (2009) |
Equation for Peak Capacity Estimation in 2D-LC | Fundamentals | Quality Descriptors | Li et al. (2009) |
Comparison of Performance of Different Comprehensive 2D-LC Approaches | Fundamentals | Quality Descriptors | Fairchild et al. (2009) |
Quantification in Comprehensive Two-Dimensional Liquid Chromatography | Chemometrics | Data Analysis | Mondello et al. (2008) |
Overview of Recent Applications of Comprehensive 2D-LC | Applications | Periodic Overview | Dugo et al. (2008) |
Optimization of 2D-LC Separations by Adjusting Selectivity and Gradients | Method Development | Optimization | Jandera et al. (2008) |
Implementations of 2D-LC | Applications | Periodic Overview | Guiochon et al. (2008) |
Comprehensive 2D-LC with Mass Spectrometry | Applications | Periodic Overview | Pól et al. (2008) |
Peak Detection Algorithm for Comprehensive 2D-LC and 2D-GC | Chemometrics | Peak Detection | Peters et al. (2007) |
Fast, comprehensive two-dimensional liquid chromatography | Fundamentals | General | Stoll et al. (2007) |
Evaluation of multivariate selectivity of multi-way LC methods | Chemometrics | Data Analysis | Cantwell et al. (2007) |
Comprehensive Multi-dimensional Chromatography for Lipid Analysis | Applications | Lipids | Dugo et al. (2007) |
Understanding Kinetics of Peak Capacity Production in Gradient LC | Fundamentals | Quality Descriptors | Wang et al. (2006) |
Protocol for Designing Comprehensive 2D-LC Systems | Method Development | General | Schoenmakers et al. (2006) |
Overview of Column Selectivity for 2D-LC | Method Development | Column Selection | Pavel Jandera (2006) |
Overview of Approaches in Comprehensive 2D-LC | Applications | Periodic Overview | Shellie et al. (2006) |
Resolution and Quantification Metric for Overlapped Peaks for Comprehensive 2D-LC | Chemometrics | Quantification | Fraga et al. (2005) |
Orthogonality of Separation in Two-Dimensional Liquid Chromatography | Fundamentals | Quality Descriptors | Gilar et al. (2005) |
Effect of Sampling Rate on Resolution in Comprehensive 2D-LC | Method Development | Optimization | Murphy et al. (1998) |