2D-LC Technical Literature

RESOURCES

Where the 2D-LC method database provides easy access to applications that have been developed since 1978, it does not contain publications that describe no dedicated application. Such studies and reviews are instead listed here in the 2D-LC technical literature database.

The search bar can be used to quickly find studies by keyword, category, authors and year.

Please contact us for any missing references or other feedback.

Search

TopicCategoryFocusReference
Technical study on use of packed loops in 2D-LCModulationInjectionKnol et al. (2023)
Technical study on segmented 2D-LCFundamentalsOptimizationHrůzová et al. (2023)
Optimizing transfer and dilution for 2D-LC with ASMModulationOptimizationPardon et al. (2023)
Recent Applications of 2D-LC in Food AnalysisFoodPeriodic OverviewLiang et al. (2022)
Feature-mining algorithm for polymer separations by 2D-LCChemometricsData AnalysisMolenaar et al. (2022)
Approaches to Circumvent Solvent Incompatibility in online 2D-LCModulationInjectionChapel et al. (2022)
Use of modelling for 2D-LC optimization for pharmaceutical separationsChemometricsOptimizationMakey et al. (2021)
Use of constant pressure in second dimension of 2D-LCSecond DimensionOptimizationShoykhet et al. (2021)
Study on use of scouting gradients for optimizationGradientsOptimizationden Uijl et al. (2021)
RPLC vs HILIC as first dimension for Phenolic Content analysis in 2D-LCFirst DimensionColumn SelectionCacciola et al. (2021)
Review on recent heart-cutting 2D-LC applicationsApplicationsPeriodic OverviewDsouza et al. (2021)
Review on multi-dimensional analysis of polyolefinsApplicationsPeriodic OverviewPasch et al. (2021)
Review on analysis comprehensive 2D-LC using ROI and MCR methodsChemometricsData AnalysisPérez-Cova et al. (2021)
Review on 3D separationsApplicationsGeneralAbdulhussain et al. (2021)
Review on 2D-LC in metabolomics and lipidomicsApplicationsPeriodic OverviewPérez-Cova et al. (2021)
Peak-tracking algorithm for 2D-LCChemometricsData AnalysisMolenaar et al. (2021)
Opportunities and challenges of LC coupled to SFCModulationSFCBurlet-Parendel et al. (2021)
Method for online reduction and digestion of mAbsApplicationsBiopharmaPot et al. (2021)
Dispersion in connection capillaries for flow-splitting interfacesFundamentalsGeneralGunnarson et al. (2021)
Bayesian optimization for 2D-LCChemometricsOptimizationBoelrijk et al. (2021)
2D-LC for antibody-based therapeutics reviewApplicationsPeriodic OverviewCamperi et al. (2021)
Review on use of chemometrics in 2D-LCChemometricsPeriodic OverviewBos et al. (2020)
Review on LC of alkaloids in herbal medicines (incl 2D-LC)ApplicationsPeriodic OverviewZhao et al. (2020)
Review on amino acid analysis by LC-MS (and 2D-LC)ApplicationsPeriodic OverviewVioli et al. (2020)
Review on 2D-LC of therapeutic oligonucleotidesApplicationsPeriodic OverviewGoyon et al. (2020)
Review on 2D-LC for food and food productsApplicationsPeriodic OverviewCacciola et al. (2020)
Review of 2D-LC for traditional Chinese medicineApplicationsPeriodic OverviewZhou et al. (2020)
Multicolumn 2D-LC Screening Workflow for Method DevelopmentMethod DevelopmentColumn SelectionWang et al. (2020)
Modeling of solute injection from modulation valve in 2D-LCModulationInjectionWeatherbee et al. (2020)
Evaluation of multilinear behavior of comprehensive 2D-LC dataChemometricsData AnalysisPérez-Cova et al. (2020)
Data Structure Driven Perspective on Chemometrics in Comprehensive 2D-LCChemometricsData AnalysisPérez-Cova (2020)
Application of 2D-LC for TCM AnalysisApplicationsPeriodic OverviewZhou et al. (2020)
Analyte breakthrough from sampling loops in 2D-LCModulationInjectionMoussa et al. (2020)
Two New Metrics for OrthogonalityFundamentalsQuality DescriptorsMommers et al. (2019)
Study on re-equilibration in HILIC as second dimensionSecond DimensionGradientsSeidl et al. (2019)
Study on partial equilibration in HILICApplicationsBiopharmaHeaton et al. (2019)
Review on online 2D-LC modulation technologyModulationPeriodic OverviewChen et al. (2019)
Recent Developments in Two-Dimensional Liquid ChromatographyApplicationsPeriodic OverviewPirok et al. (2019)
Recent advances in 2DLC for Monoclonal Antibodies and Therapeutic ProteinsApplicationsPeriodic OverviewStoll et al. (2019)
Re-equilibration in HILIC as Second-Dimension for 2D-LCSecond DimensionGradientsSeidl et al. (2019)
Outlook in Future Developments of Multi-dimensional SeparationsGeneralOutlookGroeneveld et al. (2019)
New At-Column Dilution ModulatorModulationActive InterfacesChen et al. (2019)
Multidimensional LC-MS for Metabolomics and LipidomicsApplicationsPeriodic OverviewLv et al. (2019)
Improved peak-clustering algorithmChemometricsPeak DetectionXu et al. (2019)
Immobilized-enzyme reactor for LC and future 2DLCModulationReaction ModulationWouters et al. (2019)
Hydrophobic subtraction model for 2DLC column selectionMethod DevelopmentColumn SelectionLindsey et al. (2019)
Comparison of Core-Shell and Fully-Porous particles for Second-dimensionSecond DimensionColumn TechnologyAhmad et al. (2019)
Calometric Approach for pH Measurement in LCFundamentalsInjectionLeme et al. (2019)
Band Broadening Effects in Spatial 2D-LC in Microfluidic DevicesFundamentalsSpatialAdamopoulou et al. (2019)
Applied 2D-LC in FoodomicsFoodPeriodic OverviewMontero et al. (2019)
Antibody–Drug Conjugate by 2D-LC using online digestionApplicationsBiopharmaGoyon et al. (2019)
Advance in 2D-LC Modulation TechnologyModulationPeriodic OverviewChen et al. (2019)
Size-Exclusion Chromatography with Superficially Porous ParticlesSecond DimensionColumn TechnologySchure et al. (2017)
Size-exclusion chromatography using Core-shell ParticlesSecond DimensionColumn TechnologyPirok et al. (2017)
Optimizing Separations in 2D-LCFundamentalsGeneralPirok et al. (2017)
State of the Art Tutorial for Using 2D-LCFundamentalsGeneralStoll et al. (2016)
Program for Interpretive Optimization Two-dimensional ResolutionMethod DevelopmentOptimizationPirok et al. (2016)
Practical Considerations for Comprehensive 2D-LC with RPLC in Both DimensionsMethod DevelopmentColumn SelectionLi et al. (2015)
Monolithic and Core-shell Columns in Comprehensive 2D-LCMethod DevelopmentColumn TechnologyJandera et al. (2015)
Improved Accuracy of Quantitation in 2D-LC using Multivariate Curve ResolutionChemometricsQuantificationCook et al. (2015)
Effect of Pressure Pulses on Second-dimension ColumnsModulationInjectionTalus et al. (2015)
Comparison of Orthogonality Metrics by Statistical AnalysisFundamentalsQuality DescriptorsSchure et al. (2015)
Theoretical and Practical Interest in UHPLC Technology for 2D-LCFundamentalsQuality DescriptorsSarrut et al. (2014)
Reversed-Phase Column Pairs in Comprehensive 2D-LCMethod DevelopmentColumn SelectionAllen et al. (2014)
Comparison of One and Multi-dimensional Modes LC ModesFundamentalsQuality DescriptorsDavis et al. (2014)
Application of 2D-LC in Bioanalysis of Drugs and ToxicantsApplicationsPharmaceuticalsXiao et al. (2014)
2D-LC for Analysis of Chinese Herbal MedicinesApplicationsNatural medicinesCao et al. (2014)
Comprehensive 2D Chromatography in Food AnalysisApplicationsFoodomicsTranchida et al. (2013)
Comparison of Chemometric Methods for Wine Analysis by Comprehensive 2D-LCChemometricsData AnalysisBailey et al. (2013)
Comparison between 1D-LC and Comprehensive 2D-LCGeneralTechnical ComparisonPotts et al. (2013)
2D-LC for Direct Chiral SeparationsApplicationsChiral SeparationsLeón-González et al. (2013)
Semi-automated Alignment and Quantification of Peaks in Comprehensive 2D-LCChemometricsPreprocessingAllen et al. (2012)
Principles of Online Comprehensive MDLCFundamentalsGeneralCarr et al. (2012)
Pareto-Optimality Study for Comparison of Comprehensive 2D-LC ModesFundamentalsQuality DescriptorsVanhoutte et al. (2012)
Optimum Gradient Conditions for Fast Second-dimension SeparationsSecond DimensionOptimizationHájek et al. (2012)
Method Development in Comprehensive 2D-LCMethod DevelopmentOptimizationBedani et al. (2012)
Influence of Temperature on Peak Shape for 2D-LCFundamentalsKineticsHaun et al. (2012)
Impact of Probe Solutes on Orthogonality AssessmentFundamentalsQuality DescriptorsBakain et al. (2012)
Gradients in Comprehensive 2D-LCMethod DevelopmentGradientsPavel Jandera (2012)
Feature generation from non-targeted analysis by comprehensive 2D-LCChemometricsData AnalysisReichenbach et al. (2012)
Development for Comprehensive 2D-LC Method for Charged CompoundsMethod DevelopmentOptimizationD'Attoma et al. (2012)
Determination of Peak Distribution in Comprehensive 2D-LCFundamentalsQuality DescriptorsDück et al. (2012)
Comprehensive 2D-LC Practical Impacts of Theoretical ConsiderationsMethod DevelopmentOptimizationPavel Jandera (2012)
Thermal Modulation for Multi-dimensional LC SeparationsModulationActive InterfacesVerstraeten et al. (2011)
Review of Chemometrics Applied to Comprehensive Separations from 2008-2010ChemometricsPeriodic OverviewPierce et al. (2011)
Resolution and Quantification in Comprehensive 2D-LC of Human UrineChemometricsQuality DescriptorsBailey et al. (2011)
Reconstruction of First dimension from Comprehensive 2D-LC DataChemometricsFirst DimensionAllen et al. (2011)
Optimization of Peak Capacity in Comprehensive 2D-LCMethod DevelopmentQuality DescriptorsGu et al. (2011)
Factors Effecting Quantification in Diode-array Detector 2D-LC DataChemometricsQuantificationBailey et al. (2011)
Effect of Sampling Time Effects on Resolving Power in 2D-LCMethod DevelopmentOptimizationHuang et al. (2011)
Effect of Gradient Profile and Sample Volume and Solvent to Very Fast GradientsMethod DevelopmentOptimizationJandera et al. (2011)
Effect of First-dimension Phase Selectivity in On-line Comprehensive 2D-LCFirst DimensionColumn SelectionGu et al. (2011)
Effect of First-dimension Eluent Composition in 2D-LCFirst DimensionOptimizationLi et al. (2011)
Targeted Data Extraction for Comprehensive 2D-LCChemometricsData AnalysisReichenbach et al. (2010)
Simulation of 2D-LC of Diblock CopolymersApplicationsPolymersGorbunov etal. (2010)
Selection of Parameters for Optimization of Comprehensive Off-line 2D-LCMethod DevelopmentOptimizationEeltink et al. (2010)
Second-dimension Gradient Types in Comprehensive 2D-LCSecond DimensionGradientsJandera et al. (2010)
Precision and Accuracy of Peak Quantification in Comprehensive 2D-LCChemometricsQuantificationThekkudan et al. (2010)
Optimization of 2D-LC Systems using Pareto-Optimality ApproachChemometricsOptimizationVivó-Truyols et al. (2010)
Effect of Sampling Time on Peak Capacity and Analysis Speed in Comprehensive 2D-LCMethod DevelopmentOptimizationPotts et al. (2010)
Development of Micro-Electrochemical Array Detector for 2D-LCDetectionElectrochemicalAbia et al. (2010)
2D-LC of Synthetic polymersPolymersPeriodic OverviewDušan Berek (2010)
Peak-Pattern Matching with Comprehensive 2D-LCChemometricsData AnalysisReichenbach et al. (2009)
Overview of Data Analysis Programs for 2D-LC and 2D-GCChemometricsData AnalysisKallio et al. (2009)
Overview of Comprehensive 2D-LC ApplicationsApplicationsPeriodic OverviewFrançois et al. (2009)
Optimization Strategies for Off-line 2D-LCMethod DevelopmentOptimizationHorváth et al. (2009)
Optimization of 2D-LC Gradient SeparationsMethod DevelopmentOptimizationČesla et al. (2009)
On-line Multidimensional LC using Multiple Columns in ParallelFundamentalsGeneralFairchild et al. (2009)
Generation and Limitations of Peak Capacity in 2D-LCFundamentalsQuality DescriptorsHorváth et al. (2009)
Equation for Peak Capacity Estimation in 2D-LCFundamentalsQuality DescriptorsLi et al. (2009)
Comparison of Performance of Different Comprehensive 2D-LC ApproachesFundamentalsQuality DescriptorsFairchild et al. (2009)
Quantification in Comprehensive Two-Dimensional Liquid ChromatographyChemometricsData AnalysisMondello et al. (2008)
Overview of Recent Applications of Comprehensive 2D-LCApplicationsPeriodic OverviewDugo et al. (2008)
Optimization of 2D-LC Separations by Adjusting Selectivity and GradientsMethod DevelopmentOptimizationJandera et al. (2008)
Implementations of 2D-LCApplicationsPeriodic OverviewGuiochon et al. (2008)
Comprehensive 2D-LC with Mass SpectrometryApplicationsPeriodic OverviewPól et al. (2008)
Peak Detection Algorithm for Comprehensive 2D-LC and 2D-GCChemometricsPeak DetectionPeters et al. (2007)
Fast, comprehensive two-dimensional liquid chromatographyFundamentalsGeneralStoll et al. (2007)
Evaluation of multivariate selectivity of multi-way LC methodsChemometricsData AnalysisCantwell et al. (2007)
Comprehensive Multi-dimensional Chromatography for Lipid AnalysisApplicationsLipidsDugo et al. (2007)
Understanding Kinetics of Peak Capacity Production in Gradient LCFundamentalsQuality DescriptorsWang et al. (2006)
Protocol for Designing Comprehensive 2D-LC SystemsMethod DevelopmentGeneralSchoenmakers et al. (2006)
Overview of Column Selectivity for 2D-LCMethod DevelopmentColumn SelectionPavel Jandera (2006)
Overview of Approaches in Comprehensive 2D-LCApplicationsPeriodic OverviewShellie et al. (2006)
Resolution and Quantification Metric for Overlapped Peaks for Comprehensive 2D-LCChemometricsQuantificationFraga et al. (2005)
Orthogonality of Separation in Two-Dimensional Liquid ChromatographyFundamentalsQuality DescriptorsGilar et al. (2005)
Effect of Sampling Rate on Resolution in Comprehensive 2D-LCMethod DevelopmentOptimizationMurphy et al. (1998)